_zope_interface_coptimizations.pyd is a process that runs with the Zope application server.  The term “application server” can mean several different things.  In this case, it refers to the software framework that can be used to build or house various applications.

The “.pyd” in _zope_interface_coptimizations.pyd means that it was created using the Python programming language.  Zope structures are commonly created with this language.

If you see this file on your computer, it most likely means that you have visited a Zope-based website, or one that otherwise incorporates Zope into its structure.  This file is not known to be part of any malicious software, such as a virus, Trojan, or spyware program.

It is still possible, however, that the file may have been affected by one of these malicious programs.  Anti-virus programs remove these programs but do not typically repair the damage they do to process files.  If you would like to scan your process files for damage, you can get a free scan with ZookaWare PC Cleaner.