_zope_thread.pyd is a module\r that is most commonly found in the file path: %programfiles%\plone 3\zope\lib\python\zope\thread.  Zope is a programming application used for servers, content management systems, and other applications.  PYD is an extension for the Python programming language.

_zope_thread.pyd is an entry for the Windows registry.  Files in the registry act as shortcuts to keep the Windows OS working faster.

Over time, these files can become corrupt, outdated, or infected by spyware and viruses.  A cluttered or corrupted registry can severely reduce how fast the computer runs, and even cause it to crash.

Traditionally, users have had to resort either to re-installing Windows every year or taking their computer to a PC technician (or just giving up and buying a new computer).  Today, registry cleaners can clean and repair a registry for a fraction of the effort and cost.  You can also get a free registry scan from ZookaWare PC Cleaner.