~e5.0001 is a file used by Macrovision Europe, Ltd. in the copy protection of its games.  Macrovision produces such games as Battlefield 2, Middle Earth Battles, Sim2, and at least one of the Harry Potter games.

Even users with legitimate versions of Macrovision’s games may experience problems.  Problems have included drastically slower games and general slower computing time while the company’s games are running.  Both the game interface and the computer have been reported to have crashed because of problems with the copy protection.

If you are experiencing similar problems, you might have a problem with your ~e5.0001 file.  A free scan with ZookaWare PC Cleaner will tell you what registry entries are infected, corrupt, or missing.